Beta Cell Toxicity

Discuss the relationship amid B-cell toxicity and diabetes type II; what is the role of activated type O species? Type II diabetes, non-insulin dependent, is a progressive disease characterized by insulin resistance and pancreatic B-cell inspire apoptosis which result in hyperglycemia (Mahan, Escott-Stump, & Ramond, 2012). The resulting hyperglycemia induces, and is exacerbated by irreversible B-cell toxicity, which furthers the modify effects of insulin sensitivity and insulin secernment (Mahan et al., 2012). This is supported by Robertoson, Takahashi, Tanaka, and Tran (2003), whose look for indicated that hyperglycemia associated with type 2 diabetes is a secondary exercise of beta-cell toxicity. B-cell toxicity develops over considerable exposure to high glucose preoccupation and results in damage to cellular components of insulin production that effect insulin assimilation and secretion (Robertson et al., 2003). Robertson et al. found that the thingmajig of B-cell glucose toxicity involves pancreas duodenum homeobox-1 (PDX-1), a racy regulator of insulin promoter activity. Roberson go on in vivo, that Zucker diabetic butterball (ZDF) rats lost islet B-cell deoxyribonucleic erosive binding activity of PDX-1 and insulin factor expression as they increasingly developed more prankish hyperglycemia.

In the same study, Roberson in like manner ascertained that PDX-1 and insulin were preserved, and glycemic control was improved when the ZDF rats were tough with either an antioxidant or bring down blood glucose levels. These findings suggest that B-cell toxicity is also a effect of oxidative stress. Chronic oxidative stress end-to-end the ashes is often associated with hyperglycemia because the high-spirited glucose concentrations form reactive oxygen species (ROS), and increased ROS is common in the pathogenesis of diabetes (Drews, Krippeit-Drews, & Dufer, 2010). B-cells atomic snatch 18 especially at risk as a grade for ROS. They have oddly low antioxidant defense cognitive content because they...If you urgency to get a full essay, order it on our website: Orderessay

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